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Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit . Updates regarding government operating status and resumption of normal operations can be found at .

Past Funding Opportunities

Past Funding Opportunities

Notice	Limited Competition: Continued Development of INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndromE) Project Data Coordinating Center (U2C Clinical Trial Not Allowed)
Notice Number
Release Date	November 5, 2024
Application Due Date(s)	December 12, 2024
Expiration Date	December 13, 2024
Additional Information	Frequently Asked Questions

Notice	Use of Digital Technology and Mobile Health (mHealth) to Improve Diagnosis, Assessments, Interventions, Management and Outcomes for Individuals with Down Syndrome Across the Lifespan (R21 Clinical Trial Not Allowed)
Notice Number
Release Date	January 17, 2024
Application Due Date(s)	February 16, 2024
Expiration Date	February 14, 2025

Notice	NOSI: Mentored Career Development Awards to Foster the Careers of Investigators Pursuing Research Related to Down syndrome as Part of the INCLUDE Project
Notice Number
Release Date	May 24, 2022
Expiration Date	November 13, 2024

Notice	Developing Academic Research Enhancement Award (AREA) and Research Enhancement Award Program (REAP) for Institutions with an emphasis on Down syndrome research (R15 Clinical Trial Not Allowed)
Notice Number
Release Date	May 31, 2022
Expiration Date	April 11, 2025

Notice	NOSI: NIH Research Project Grants on Down Syndrome (R01) for the INCLUDE Project
Notice Number
Release Date	May 26, 2022
Expiration Date	May 1, 2025

Notice	Clinical Trials Development for Co-Occurring Conditions in Individuals with Down syndrome: Phased Awards for INCLUDE (R61/R33 Clinical Trial Required)
Notice Number
Release Date	April 5, 2022
Application Due Date(s)	June 30, 2023; July 1, 2024

Notice	INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Trial Readiness (R21 Clinical Trial Not Allowed)
Notice Number
Release Date	April 5, 2022
Application Due Date(s)	July 1, 2023; July 1, 2024
Expiration Date	July 2, 2024

Notice	Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed)
Notice Number
Release Date	April 5, 2022
Application Due Date(s)	July 1, 2023; July 1, 2024
Expiration Date	July 2, 2024

Notice	Small Research Grants for Analysis, Curation, and/or Sharing of Down syndrome-related Research Data for the INCLUDE Project (R03 Clinical Trial Not Allowed)
Notice Number
Release Date	April 8, 2022
Application Due Date(s)	June 30, 2023; July 1, 2024
Expiration Date	July 2, 2024

Notice	INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Exploratory/Developmental Research Grant Award (R21 Clinical Trial Not Allowed)
Notice Number
Release Date	October 3, 2021
Application Due Date(s)	July 1, 2023; July 1, 2024
Expiration Date	July 2, 2024

Notice	Notice of Special Interest (NOSI): Administrative Supplements to NCATS CTSA Program KL2/K12 Institutional Career Development Awards as part of the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project
Notice Number
Release Date	October 3, 2022
Application Due Date(s)	July 1, 2023; July 1, 2024; July 1, 2025
Expiration Date	July 2, 2025

Notice	Notice of Special Interest (NOSI): Administrative Supplements to NCATS CTSA Program T32/TL1 Institutional Training Program as part of the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project
Notice Number
Release Date	Spetember 30, 2022
Application Due Date(s)	July 1, 2023; July 1, 2024; July 1, 2025
Expiration Date	July 2, 2025

Notice	NOSI: Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship Awards to Support Training in Research Related to DS as Part of the INCLUDE Project
Notice Number
Release Date	May 18, 2022
Expiration Date	April 9, 2024

Notice	DS-Connect®: The Down Syndrome Registry (OT2 Clinical Trial Optional)
Notice Number
Release Date	February 5, 2024
Application Due Date	February 20, 2024

Notice	Notice of Intent to Publish Notice of Funding Opportunity Announcements for a Federated Biobanking resource for the Down Syndrome Cohort Study Program (DS-CDP) across the lifespan for the INCLUDE Project
Notice Number
Release Date	June 02, 2023
Application Due Date	November 01, 2023
Earliest Estimated Award Date	July 1, 2024
Earliest Estimated Start Date	July 1, 2024
Additional Information	Frequently Asked Questions

Notice	Notice of Intent to Publish Notice of Funding Opportunity Announcements for a Down Syndrome Clinical Cohort Coordinating Center (DS-4C) for the INCLUDE Project
Notice Number
Release Date	June 02, 2023
Application Due Date	November 01, 2023
Earliest Estimated Award Date	July 1, 2024
Earliest Estimated Start Date	July 1, 2024
Additional Information	Frequently Asked Questions

Notice	Notice of Intent to Publish Notice of Funding Opportunity Announcements for Down Syndrome Cohort Research Sites (DS-CRS) for the Down Syndrome Cohort Study Program (DS-CDP) across the lifespan for the INCLUDE Project
Notice Number
Release Date	June 02, 2023
Application Due Date	November 01, 2023
Earliest Estimated Award Date	July 1, 2024
Earliest Estimated Start Date	July 1, 2024
Additional Information	Frequently Asked Questions

Notice	Notice of Special Interest (NOSI): Use of Digital Technology and Mobile Health (mHealth) to Improve Diagnosis, Assessments, Interventions, Management and Outcomes for Individuals with Down Syndrome Across the Lifespan (R21 Clinical Trial Not Allowed)
Notice Number
Release Date	June 28, 2021
Expiration Date	November 17, 2023

Notice	Down Syndrome Cohort Research Sites (DS-CRS) for the Down Syndrome Cohort Study Program (DS-CDP) across the lifespan for the INCLUDE Project (U01 Clinical Trial Not Allowed)
Notice Number
Release Date	October 20, 2023
Application Due Date	December 15, 2023
Expiration Date	December 16, 2023
Additional Information	Frequently Asked Questions

Notice	Federated Biobanking resource for the Down Syndrome Cohort Study Program (DS-CDP) across the lifespan for the INCLUDE Project NOT-OD-23-136
Notice Number
Release Date	October 20, 2023
Application Due Date	December 15, 2023
Expiration Date	December 16, 2023
Additional Information	Frequently Asked Questions

Notice	Down Syndrome Clinical Cohort Coordinating Center (DS-4C) for the INCLUDE Project (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) (U54 Clinical Trial Not Allowed)
Notice Number
Release Date	October 20, 2023
Application Due Date	January 26, 2024
Expiration Date	January 27, 2024
Additional Information	Frequently Asked Questions

Notice	INCLUDE (Investigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 Clinical Trial Not Allowed)
Notice Number
Release Date	May 8, 2023
Application Due Date(s)	July 1, 2023
Expiration Date	July 2, 2023

Notice	Notice of Special Interest (NOSI): Discovery of the Genetic Basis of Conditions Associated with Down Syndrome for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project (X01)
Notice Number
Release Date	February 8, 2023
Application Due Date(s)	March 21, 2023
Expiration Date	March 22, 2023

Notice	Notice of Change to NOT-OD-20-025: Notice of Special Interest (NOSI): NIH Research Project Grants on Down Syndrome (R01) for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project
Notice Number
Release Date	March 19, 2021
Application Due Date(s)	June 5, 2021, October 5, 2021
Expiration Date	January 7, 2022

Notice	Notice of Change to NOT-OD-20-024: Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project
Notice Number
Release Date	March 19, 2021
Application Due Date(s)	May 12, 2021, July 23, 2021, November 23, 2021, March 23, 2022, July 23, 2022
Expiration Date	July 24, 2022

Notice	Notice of Special Interest (NOSI): Competitive Supplements/Revisions (R01) Available for INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndromE) Project (Competitive Supplement/Revision Clinical Trial Optional)
Notice Number
Release Date	December 18, 2019
Application Due Date(s)	March 5, 2021; July 5, 2021; November 5, 2021; March 5, 2022; July 5, 2022
Expiration Date	September 8, 2022

Notice	Notice of Special Interest (NOSI): Development of Animal Models of Down Syndrome and Related Biological Materials as Part of the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project
Notice Number
Release Date	December 18, 2019
Application Due Date(s)	For R24 applications submitted via : May 26, 2021, September 28, 2021 and January 26, 2022, May 26, 2022 For R21 applications submitted via : February 16, 2021; June 16, 2021; October 16, 2021; February 16, 2022; June 16, 2022
Expiration Date	September 9, 2022

Notice	Notice of Special Interest (NOSI): Administrative Supplements to NCATS CTSA Program KL2 Institutional Career Development Awards as part of the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project
Notice Number
Release Date	September 25, 2020
Application Due Date(s)	November 1, 2021, November 1, 2022
Expiration Date	November 2, 2022

Notice	Notice of Special Interest (NOSI): Availability of Administrative Supplements for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project
Notice Number
Release Date	December 18, 2019
Application Due Date(s)	March 23, 2021; March 23, 2022
Expiration Date	March 24, 2022

Notice	Notice of Special Interest: Mentored Career Development Awards to Foster the Careers of Investigators Pursuing Research Related to Down syndrome as Part of the INCLUDE Project
Notice Number
Release Date	December 6, 2019
Application Due Date(s)	February 12, 2021; June 12, 2021; October 12, 2021
Expiration Date	January 8, 2022

Notice	Notice of Special Interest: Ruth L. Kirschstein National Research Service Award (NRSA) Fellowship Awards to Support Training in Research Related to Down Syndrome as Part of the INCLUDE Project
Notice Number
Release Date	December 6, 2019
Application Due Date(s)	April 8, 2021; August 8, 2021; December 8, 2021
Expiration Date	January 8, 2022

Notice	Notice of Special Interest (NOSI): NIH Research Project Grants on Down Syndrome (R01) for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project
Notice Number
Release Date	December 18, 2019
Application Due Date(s)	February 5, 2021; June 5, 2021; October 5, 2021
Expiration Date	January 8, 2022

Notice	Notice of Special Interest (NOSI) regarding the Availability of Urgent Competitive Revisions and Administrative Supplements for Research on Coronavirus Disease 2019 (COVID-19) in Individuals with Down Syndrome for the INCLUDE Project
Notice Number
Release Date	June 25, 2020
Application Due Date(s)	March 12, 2021, July 12, 2021
Expiration Date	July 13, 2021

Notice	Clinical Trials Development for Co-Occurring Conditions in Individuals with Down syndrome: Phased Awards for INCLUDE (R61/R33 Clinical Trial Required)
Notice Number
Release Date	December 13, 2019
Application Due Date(s)	November 3, 2021
Expiration Date	November 4, 2021

Notice	INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Trial Readiness (R21 Clinical Trial Not Allowed)
Notice Number
Release Date	December 13, 2019
Application Due Date(s)	November 3, 2021
Expiration Date	November 4, 2021

Notice	Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 Clinical Trial Not Allowed)
Notice Number
Release Date	December 13, 2019
Application Due Date(s)	November 3, 2021
Expiration Date	November 4, 2021

Notice	Small Research Grants for Analyses of Down Syndrome-related Research Data for the INCLUDE Project (R03 Clinical Trial Not Allowed)
Notice Number
Release Date	December 13, 2019
Application Due Date(s)	November 3, 2021
Expiration Date	November 4, 2021

Notice	Notice of Special Interest (NOSI): Discovery of the Genetic Basis of Conditions Associated with Down Syndrome for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project (X01)
Notice Number
Release Date	December 16, 2020
Expiration Date	February 20, 2021

Notice	Notice of Special Interest (NOSI): Discovery of the Genetic Basis of Conditions Associated with Down Syndrome for the INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Project (X01)
Notice Number
Release Date	January 28, 2022
Expiration Date	March 01, 2022

Notice	Notice of Special Interest (NOSI): Administrative Supplements to NCATS CTSA Program KL2 Institutional Career Development Awards as part of the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project
Notice Number
Release Date	December 19, 2019
Expiration Date	March 3, 2020

Notice	Development of the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndromE) Project Data Coordinating Center (U2C)
Notice Number
Post Date	December 13, 2019
Expiration Date	February 15, 2020
More Information	The application consists of four components: Overall, Administrative and Outreach Core, Data Portal Core and Data Management Cores. Each component is allowed a Research Strategy section up to 12 pages and each will have a budget section. FAQ from INCLUDE Data Coordinating Center Pre-Application Webinar that INCLUDE Program staff hosted for prospective applicants.

Notice	Notice of Clarification of Application Submission Information for NOT-OD-19-071 "Notice of Availability of Competitive Supplements/Revisions for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndromE) Project
Notice Number
Post Date	February 27, 2019
Expiration Date	March 20, 2019

Notice	INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Clinical Trial Readiness (R21 Clinical Trial Not Allowed)
Notice Number
Post Date	February 5, 2019
Expiration Date	March 15, 2019

Notice	Transformative Research Award for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndrome) Project (R01 – Clinical Trial Not Allowed)
Notice Number
Post Date	February 5, 2019
Expiration Date	March 15, 2019

Notice	Clinical Trials Development for Co-Occurring Conditions in Individuals with Down syndrome: Phased Awards for INCLUDE (R61/R33 Clinical Trials Required)
Notice Number
Post Date	February 5, 2019
Expiration Date	March 15, 2019

Notice	Notice of Availability of Competitive Supplements/Revisions for the INCLUDE (Investigation of Co-occurring Conditions across the Lifespan to Understand Down syndromE) Project (Competitive Supplement/Revision Clinical Trial Optional)
Notice Number
Post Date	February 5, 2019
Expiration Date	See listed due dates in Notice.

This page last reviewed on July 16, 2025

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